An introduction to

Polynucleotide Treatment

Polynucleotidess as an injectable skin treatment, becoming an increasingly popular solution amongst patients for treating the signs of ageing and other common skin complaints. Sometimes also referred to as Biostimulators, Biofillers or Biorevitalisers, they improve deep skin and tissues renewal on a cellular level by inducing collagen and elastin production which help improves the structural support layer within the skin that keeps us looking youthful.


Polynucleotides are a natural, biodegradable component predominantly derived from salmon DNA. They are made from long chains of nucleotides; the biological molecules that are the building blocks of DNA. They create an optimal environment for fibroblast growth – essential cells for tissue repair and regeneration. The chains also attract and bind water molecules, allowing them to provide a strong moisturising effect, which can contribute to improved tissue elasticity. In addition, they have a remarkable anti-free radical action. They counteract the skin damage, which can accumulate due to various stressors, including cellular damage, stress, and exposure to UV rays, giving them a protective role in reducing cell damage.


Suitable for any area of the skin, including:

  • Face
  • Scalp for hair re-growth
  • Targeted application to small areas such as the under-eye, forehead, or mouth area



  • Unlike injectables that temporarily plump the skin, polynucleotides have been scientifically proven to regenerate skin at the cellular level, increasing hydration levels, collagen production, skin elasticity and more.
  • Improvements in skin can be seen in just a few weeks or when combined with hyaluronic acid, results can be seen instantly
  • Non-surgical procedure.
  • The benefits of treatment usually last 6 – 12  months.
  • There is minimal downtime after the procedure.
  • Arrive at the clinic on the day of the procedure with clean washed face and without make-up.
  • To reduce the risk of bruising it may be beneficial to stop the use of elective medicines such as aspirin, or anti-inflammatory medications (i.e., Ibuprofen, Naproxen) for 24 hours prior to treatment.
  • It’s recommended to avoid drinking alcohol for 24 hours before the procedure.
  • If you have a history of a Herpes your clinician will consider an anti-viral treatment such as Zovirax one day prior to treatment and for 7 days post treatment.

The mechanical action of the needle may cause minor blood effusions. The swellings at the infiltration site usually heal within a short time (a few hours), although this may take longer depending on the patient’s subjective characteristics, the area treated (e.g., neck or around the eyes), and the infiltration technique. They may continue to be visible for several days. 

In rare cases, reactions common to all types of injections, such as swelling, erythema and a sensation of heat or pain, may occur in the area treated. These usually clear up within a few hours. To speed up healing, ice may be applied to the treated area. If these symptoms persist, please refer to a physician.

This treatment is not suitable if you have any of the following:

The Polynucleotide Treatment should not be used on patients who:

  • Who are allergic to fish or fish products
  • Are vegan
  • Hypersensitivity or those with severe allergies.
  • Areas with active inflammation or infections (e.g., cysts, pimples, rashes, hives, warts or open wounds).
  • Cases of active Herpes simplex.
  • Pregnant or Breastfeeding.
  • Any form of skin cancer in the treatment area.
  • Bleeding disorders and dysfunctions e.g., Haemophilia, Von Willebrand disease and prescribed medications for blood thinning such as Heparin, Warfarin.
  • Received Isotretinoin treatment (such as Accutane or Roaccutane) in the past 12 months.
  • Compromised immune system due to immunosuppression-related skin diseases (e.g.Vitiligo, Lupus etc)

Call 01283 701345 to book your appointment.